Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

Proteasomal protein degradation is a key determinant of protein half-life and hence of cellular processes ranging from basic metabolism to a host of immunological processes. Despite its importance the mechanisms regulating proteasome activity are only incompletely understood. Here we use an iterativ...

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Bibliographic Details
Main Authors: Juliane Liepe, Hermann-Georg Holzhütter, Elena Bellavista, Peter M Kloetzel, Michael PH Stumpf, Michele Mishto
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
experimental design
functional analysis
proteasome regulation
proteasome structure
Bayesian analysis
Online Access:https://elifesciences.org/articles/07545

Internet

https://elifesciences.org/articles/07545

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