Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52

Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52

Abstract Objective Human variants in voltage‐gated sodium channel (VGSC) α and β subunit genes are linked to developmental and epileptic encephalopathies (DEEs). Inherited, biallelic, loss‐of‐function variants in SCN1B, encoding the β1/β1B subunits, are linked to early infantile DEE (EIEE52). De nov...

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Bibliographic Details
Main Authors: Jacob M. Hull, Heather A. O’Malley, Chunling Chen, Yukun Yuan, Nicholas Denomme, Alexandra A. Bouza, Charles Anumonwo, Luis F. Lopez‐Santiago, Lori L. Isom
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51205

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https://doi.org/10.1002/acn3.51205

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