Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.

Trans-activation Response DNA-binding Protein-43 (TDP-43) lesions are observed in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration with ubiquitin inclusions (FTLD-TDP) and 25-50% of Alzheimer's Disease (AD) cases. These abnormal protein inclusions are composed of either am...

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Bibliographic Details
Main Authors: Yari Carlomagno, Yongjie Zhang, Mary Davis, Wen-Lang Lin, Casey Cook, Judy Dunmore, William Tay, Kyle Menkosky, Xiangkun Cao, Leonard Petrucelli, Michael Deture
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3942448?pdf=render

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http://europepmc.org/articles/PMC3942448?pdf=render

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