Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

Abstract Background CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRISPR-Cas9 gene-editing has not yet been assessed. R...

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Bibliographic Details
Main Authors: Emanuel Gonçalves, Fiona M. Behan, Sandra Louzada, Damien Arnol, Euan A. Stronach, Fengtang Yang, Kosuke Yusa, Oliver Stegle, Francesco Iorio, Mathew J. Garnett
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Biology
Subjects:
CRISPR
Structural rearrangements
Ploidy
Copy-number
Crispy
Online Access:http://link.springer.com/article/10.1186/s13059-019-1637-z

Internet

http://link.springer.com/article/10.1186/s13059-019-1637-z

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