Expression profiling suggests underexpression of the GABAA receptor subunit δ in the fragile X knockout mouse model

Expression profiling suggests underexpression of the GABAA receptor subunit δ in the fragile X knockout mouse model

It is still unclear why absence of the fragile X protein (FMRP) leads to mental retardation and specific behavioral problems. In neurons, the protein transports specific mRNAs towards the actively translating ribosomes near the synapses.To unravel the mechanism leading to the disorder, we performed...

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Bibliographic Details
Main Authors: Ilse Gantois, Jo Vandesompele, Frank Speleman, Edwin Reyniers, Rudi D'Hooge, Lies-Anne Severijnen, Rob Willemsen, Flora Tassone, R. Frank Kooy
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
Fragile X knockout mouse
GABAA receptor subunit δ
Rho guanine exchange factor 12
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002135

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http://www.sciencedirect.com/science/article/pii/S0969996105002135

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