Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios

Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios

Abstract Introduction We tested the hypothesis that the amyloid β (Aβ) peptide ratios are more stable than Aβ42 alone when biofluids are exposed to two preanalytical conditions known to modify measurable Aβ concentration. Methods Human cerebrospinal fluid (CSF) and culture media (CM) from human cort...

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Bibliographic Details
Main Authors: Jamie Toombs, Martha S. Foiani, Henrietta Wellington, Ross W. Paterson, Charles Arber, Amanda Heslegrave, Michael P. Lunn, Jonathan M. Schott, Selina Wray, Henrik Zetterberg
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
Amyloid β ratio
Preanalytical factors
Cerebrospinal fluid
Cell culture media
Surface adsorption
Online Access:https://doi.org/10.1016/j.dadm.2018.02.005

Internet

https://doi.org/10.1016/j.dadm.2018.02.005

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