Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

Abstract Introduction The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins exploit the multienzyme super elongation complex leading to elevated...

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Bibliographic Details
Main Authors: Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Michael Steckel, Ashley L. Eheim, Andrea Haegebarth, Carlo Stresemann
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia (AML)
Acute lymphoblastic leukemia (ALL)
MLL-fusion
Menin-MLL
DOT1L
DHODH
Online Access:http://link.springer.com/article/10.1186/s13045-019-0749-y

Internet

http://link.springer.com/article/10.1186/s13045-019-0749-y

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