RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice

RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice

Transplantation of hematopoietic stem/progenitor cells (HSPC) modified with a lentiviral vector bearing a potent nontoxic short hairpin RNA (sh1005) directed to the HIV coreceptor CCR5 is capable of continuously producing CCR5 downregulated CD4+ T lymphocytes. Here, we characterized HIV-1 resistance...

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Bibliographic Details
Main Authors: Saki Shimizu, Gene-Errol Ringpis, Matthew D Marsden, Ruth V Cortado, Holly M Wilhalme, David Elashoff, Jerome A Zack, Irvin S Y Chen, Dong Sung An
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
CCR5
shRNA
HIV-1 Gene Therapy
Hematopoietic stem cells
Humanized mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300142

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http://www.sciencedirect.com/science/article/pii/S2162253116300142

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