Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.

Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.

Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variations in normal tissues due to agin...

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Bibliographic Details
Main Authors: Brock C Christensen, E Andres Houseman, Carmen J Marsit, Shichun Zheng, Margaret R Wrensch, Joseph L Wiemels, Heather H Nelson, Margaret R Karagas, James F Padbury, Raphael Bueno, David J Sugarbaker, Ru-Fang Yeh, John K Wiencke, Karl T Kelsey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2718614?pdf=render

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http://europepmc.org/articles/PMC2718614?pdf=render

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