Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors

Targeted therapies for solid tumors in children, adolescents, and young adults (C-AYA) lag behind that of adult carcinomas. Here, the authors study the germline genomic signatures of 1,507 C-AYA patients with solid tumors and find pathogenic/likely pathogenic germline variants in diverse genes of wh...

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Bibliographic Details
Main Authors: Sara Akhavanfard, Roshan Padmanabhan, Lamis Yehia, Feixiong Cheng, Charis Eng
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16067-1