The Limits of Linked Suppression for Regulatory T cells

The Limits of Linked Suppression for Regulatory T cells

Background: We have previously found that CD4+CD25+ regulatory T cells (T regs) can adoptively transfer tolerance after its induction with co-stimulatory blockade in a mouse model of murine cardiac allograft transplantation. In these experiments, we tested an hypothesis with three components: 1) th...

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Bibliographic Details
Main Authors: Toshiro eIto, Akira eYamada, Ibrahim eBatal, Melissa Y Yeung, Martina eMcGrath, Mohamed H. Sayegh, Anil eChandraker, Takuya eUeno
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
tolerance
regulatory T cells
Co-stimulation
Indirect pathway
MHC class II
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00082/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00082/full

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