The utility of in vitro trials that use Caco-2 cell systems as a replacement for animal intestinal permeability and human bioequivalence measurements in drug development
Caco-2 cells have been widely used for in vitro intestinal permeability screening of new molecules in drug development but with some pitfalls. Limiting the application of Caco-2 permeability screening to passive compounds is difficult as the majority of approved drugs include both passive diffusion...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
ALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da Saúde
2015-04-01
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Series: | Journal Biomedical and Biopharmaceutical Research (BBR) |
Subjects: | |
Online Access: | http://www.alies.pt/BBR%20Editions/Vol-12-1-2015/art11_12n1.pdf |