The utility of in vitro trials that use Caco-2 cell systems as a replacement for animal intestinal permeability and human bioequivalence measurements in drug development

Caco-2 cells have been widely used for in vitro intestinal permeability screening of new molecules in drug development but with some pitfalls. Limiting the application of Caco-2 permeability screening to passive compounds is difficult as the majority of approved drugs include both passive diffusion...

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Bibliographic Details
Main Authors: Margarida Estudante, Cristina de Mello-Sampayo, Selma Sahin, José Morais, Leslie Z. Benet
Format: Article
Language:English
Published: ALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da Saúde 2015-04-01
Series:Journal Biomedical and Biopharmaceutical Research (BBR)
Subjects:
Online Access:http://www.alies.pt/BBR%20Editions/Vol-12-1-2015/art11_12n1.pdf