Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection

Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection

Multi-parent populations (MPPs) capture and maintain the genetic diversity from multiple inbred founder strains to provide a resource for high-resolution genetic mapping through the accumulation of recombination events over many generations. Breeding designs that maintain a large effective populatio...

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Bibliographic Details
Main Authors: Elissa J. Chesler, Daniel M. Gatti, Andrew P. Morgan, Marge Strobel, Laura Trepanier, Denesa Oberbeck, Shannon McWeeney, Robert Hitzemann, Martin Ferris, Rachel McMullan, Amelia Clayshultle, Timothy A. Bell, Fernando Pardo Manuel de Villena, Gary A. Churchill
Format: Article
Language:English
Published: Oxford University Press 2016-12-01
Series:G3: Genes, Genomes, Genetics
Subjects:
transmission ratio distortion
meiotic drive
aneuploidy
Multiparent Advanced Generation Inter-Cross (MAGIC)
multiparental populations MPP
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.035527

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http://g3journal.org/lookup/doi/10.1534/g3.116.035527

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