Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes—An Artifact by Big Conductance Calcium Activated Potassium Current (I<sub>bk,Ca</sub>)

Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes—An Artifact by Big Conductance Calcium Activated Potassium Current (I<sub>bk,Ca</sub>)

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent an unlimited source of human CMs that could be a standard tool in drug research. However, there is concern whether hiPSC-CMs express all cardiac ion channels at physiological level and whether they might express non-car...

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Bibliographic Details
Main Authors: András Horváth, Torsten Christ, Jussi T. Koivumäki, Maksymilian Prondzynski, Antonia T. L. Zech, Michael Spohn, Umber Saleem, Ingra Mannhardt, Bärbel Ulmer, Evaldas Girdauskas, Christian Meyer, Arne Hansen, Thomas Eschenhagen, Marc D. Lemoine
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
human induced pluripotent stem cell-derived cardiomyocytes (hipsc-cms)
ips cells
stem cells
big conductance calcium activated potassium channel (bk)
maxi-k
slo1
k<sub>ca1.1</sub>
iberiotoxin
long qt syndrome
Online Access:https://www.mdpi.com/2073-4409/9/1/253

Internet

https://www.mdpi.com/2073-4409/9/1/253

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