A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for exploring and understanding effective drug combinations....

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Bibliographic Details
Main Authors: Ravi S. Narayan, Piet Molenaar, Jian Teng, Fleur M. G. Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C. Lecca, Kristiaan J. Lenos, Sjors G. J. G. In ‘t Veld, Wessel van Wieringen, Frederick F. Lang, Erik Sulman, Roel Verhaak, Brigitta G. Baumert, Lucas J. A. Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J. Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A. Tannous, Tom Wurdinger, Jan Koster, Bart A. Westerman
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16735-2

Internet

https://doi.org/10.1038/s41467-020-16735-2

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