Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

Summary: To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD, and PSP. We uncover a complex temporal trajectory...

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Bibliographic Details
Main Authors: Jessica E. Rexach, Damon Polioudakis, Anna Yin, Vivek Swarup, Timothy S. Chang, Tam Nguyen, Arjun Sarkar, Lawrence Chen, Jerry Huang, Li-Chun Lin, William Seeley, John Q. Trojanowski, Dheeraj Malhotra, Daniel H. Geschwind
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
chemical genomics
systems biology
transcriptomics
neurodegeneration
inflammasome
interferon
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313875

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http://www.sciencedirect.com/science/article/pii/S2211124720313875

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