Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in MiceSummary

Background & Aims: Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality, with no Food and Drug Administrationâapproved therapy. Chronic alcohol consumption causes a pro-oxidant environment and increases hepatic lipid peroxidation, with acrolein being the most reactive/t...

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Bibliographic Details
Main Authors: Wei-Yang Chen, Jingwen Zhang, Smita Ghare, Shirish Barve, Craig McClain, Swati Joshi-Barve
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X16300509