Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

Lower-limb ischemia-reperfusion (IR) is frequent and associated with significant morbidity and mortality. Phosphodiesterase 5 inhibitors demonstrated antioxidant and beneficial effects in several organs submitted to IR, but their effects on muscle mitochondrial functions after lower-limb IR are unkn...

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Bibliographic Details
Main Authors: Liliane Tetsi, Anne-Laure Charles, Isabelle Georg, Fabienne Goupilleau, Anne Lejay, Samy Talha, Myriam Maumy-Bertrand, Claire Lugnier, Bernard Geny
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Antioxidants
Subjects:
cyclic nucleotide phosphodiesterase
sildenafil
muscle
ischemia
reperfusion
peripheral arterial disease
mitochondria
reactive oxygen species
oxidative stress
calcic retention capacity
Online Access:https://www.mdpi.com/2076-3921/8/4/93

Internet

https://www.mdpi.com/2076-3921/8/4/93

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