Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distin...

Full description

Bibliographic Details
Main Authors: Michael W. Beck, Jeffrey S. Derrick, Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim, Joo-Yong Lee, Brandon T. Ruotolo, Mi Hee Lim
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13115

Internet

https://doi.org/10.1038/ncomms13115

Similar Items