Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distin...
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2016-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms13115 |
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doaj-38e022ffa1474e819049faf03deff89d2021-05-11T11:11:26ZengNature Publishing GroupNature Communications2041-17232016-10-017111310.1038/ncomms13115Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s diseaseMichael W. Beck0Jeffrey S. Derrick1Richard A. Kerr2Shin Bi Oh3Woo Jong Cho4Shin Jung C. Lee5Yonghwan Ji6Jiyeon Han7Zahra Aliakbar Tehrani8Nayoung Suh9Sujeong Kim10Scott D. Larsen11Kwang S. Kim12Joo-Yong Lee13Brandon T. Ruotolo14Mi Hee Lim15Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, University of MichiganAsan Institute for Life Sciences, Asan Medical CenterSchool of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Asan Institute for Life Sciences, Asan Medical CenterAsan Institute for Life Sciences, Asan Medical CenterDepartment of Medicinal Chemistry, University of MichiganDepartment of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Asan Institute for Life Sciences, Asan Medical CenterDepartment of Chemistry, University of MichiganDepartment of Chemistry, Ulsan National Institute of Science and Technology (UNIST)To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology.https://doi.org/10.1038/ncomms13115 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim |
spellingShingle |
Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease Nature Communications |
author_facet |
Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim |
author_sort |
Michael W. Beck |
title |
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease |
title_short |
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease |
title_full |
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease |
title_fullStr |
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease |
title_full_unstemmed |
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease |
title_sort |
structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in alzheimer’s disease |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-10-01 |
description |
To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology. |
url |
https://doi.org/10.1038/ncomms13115 |
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