Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distin...

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Main Authors:	Michael W. Beck, Jeffrey S. Derrick, Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim, Joo-Yong Lee, Brandon T. Ruotolo, Mi Hee Lim
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13115

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spelling	doaj-38e022ffa1474e819049faf03deff89d2021-05-11T11:11:26ZengNature Publishing GroupNature Communications2041-17232016-10-017111310.1038/ncomms13115Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s diseaseMichael W. Beck0Jeffrey S. Derrick1Richard A. Kerr2Shin Bi Oh3Woo Jong Cho4Shin Jung C. Lee5Yonghwan Ji6Jiyeon Han7Zahra Aliakbar Tehrani8Nayoung Suh9Sujeong Kim10Scott D. Larsen11Kwang S. Kim12Joo-Yong Lee13Brandon T. Ruotolo14Mi Hee Lim15Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, University of MichiganAsan Institute for Life Sciences, Asan Medical CenterSchool of Life Sciences, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Asan Institute for Life Sciences, Asan Medical CenterAsan Institute for Life Sciences, Asan Medical CenterDepartment of Medicinal Chemistry, University of MichiganDepartment of Chemistry, Ulsan National Institute of Science and Technology (UNIST)Asan Institute for Life Sciences, Asan Medical CenterDepartment of Chemistry, University of MichiganDepartment of Chemistry, Ulsan National Institute of Science and Technology (UNIST)To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology.https://doi.org/10.1038/ncomms13115
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim
spellingShingle	Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease Nature Communications
author_facet	Michael W. Beck Jeffrey S. Derrick Richard A. Kerr Shin Bi Oh Woo Jong Cho Shin Jung C. Lee Yonghwan Ji Jiyeon Han Zahra Aliakbar Tehrani Nayoung Suh Sujeong Kim Scott D. Larsen Kwang S. Kim Joo-Yong Lee Brandon T. Ruotolo Mi Hee Lim
author_sort	Michael W. Beck
title	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_short	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_full	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_fullStr	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_full_unstemmed	Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease
title_sort	structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in alzheimer’s disease
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-10-01
description	To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology.
url	https://doi.org/10.1038/ncomms13115
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Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

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