High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy

High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membrane and the extracellular matrix. Overexpression of sarcospan (SSPN) in t...

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Bibliographic Details
Main Authors: Cynthia Shu, Liubov Parfenova, Ekaterina Mokhonova, Judd R. Collado, Robert Damoiseaux, Jesus Campagna, Varghese John, Rachelle H. Crosbie
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Skeletal Muscle
Subjects:
Drug discovery
Duchenne muscular dystrophy
Dystrophin
High-throughput screen
Sarcolemma
Sarcospan
Online Access:http://link.springer.com/article/10.1186/s13395-020-00244-3

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http://link.springer.com/article/10.1186/s13395-020-00244-3

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