A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration

A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation (DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect the epigenetic profiles in brain, but their contribution to AD-associated DNAm changes has been poorly investi...

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Bibliographic Details
Main Authors: Camilla Pellegrini, Chiara Pirazzini, Claudia Sala, Luisa Sambati, Igor Yusipov, Alena Kalyakulina, Francesco Ravaioli, Katarzyna M. Kwiatkowska, Danielle F. Durso, Mikhail Ivanchenko, Daniela Monti, Raffaele Lodi, Claudio Franceschi, Pietro Cortelli, Paolo Garagnani, Maria Giulia Bacalini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
DNA methylation
Alzheimer's disease
brain
sex
aging
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.639428/full

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