The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

by Noémie Gensous, Claudio Franceschi, Aurelia Santoro, Maddalena Milazzo, Paolo Garagnani, Maria Giulia Bacalini
Published 2019-04-01

Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.

by Fabio Ciccarone, Francesca Gioia Klinger, Angela Catizone, Roberta Calabrese, Michele Zampieri, Maria Giulia Bacalini, Massimo De Felici, Paola Caiafa
Published 2012-01-01

Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring

by Federico Sizzano, Sebastiano Collino, Ornella Cominetti, Daniela Monti, Paolo Garagnani, Rita Ostan, Chiara Pirazzini, Maria Giulia Bacalini, Daniela Mari, Giuseppe Passarino, Claudio Franceschi, Alessio Palini
Published 2018-01-01

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

by Noémie Gensous, Francesco Ravaioli, Chiara Pirazzini, Roberto Gramignoli, Ewa Ellis, Gianluca Storci, Miriam Capri, Stephen Strom, Ezio Laconi, Claudio Franceschi, Paolo Garagnani, Fabio Marongiu, Maria Giulia Bacalini
Published 2020-01-01

Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans

by Noémie Gensous, Maria Giulia Bacalini, Claudio Franceschi, Claudio Franceschi, Carel G. M. Meskers, Andrea B. Maier, Andrea B. Maier, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani
Published 2019-08-01

Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.

by Michele Zampieri, Claudio Passananti, Roberta Calabrese, Mariagrazia Perilli, Nicoletta Corbi, Fabiana De Cave, Tiziana Guastafierro, Maria Giulia Bacalini, Anna Reale, Gianfranco Amicosante, Lilia Calabrese, Jordanka Zlatanova, Paola Caiafa
Published 2009-01-01

N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters.

by Roberto Testa, Valerie Vanhooren, Anna Rita Bonfigli, Massimo Boemi, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Liana Spazzafumo, Vincenzo Borelli, Maria Giulia Bacalini, Stefano Salvioli, Paolo Garagnani, Sylviane Dewaele, Claude Libert, Claudio Franceschi
Published 2015-01-01

The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms

by Paolo Garagnani, Chiara Pirazzini, Cristina Giuliani, Marco Candela, Patrizia Brigidi, Federica Sevini, Donata Luiselli, Maria Giulia Bacalini, Stefano Salvioli, Miriam Capri, Daniela Monti, Daniela Mari, Sebastiano Collino, Massimo Delledonne, Patrick Descombes, Claudio Franceschi
Published 2014-01-01

Analysis of Epigenetic Age Predictors in Pain-Related Conditions

by Katarzyna Malgorzata Kwiatkowska, Maria Giulia Bacalini, Claudia Sala, Helena Kaziyama, Daniel Ciampi de Andrade, Daniel Ciampi de Andrade, Rossana Terlizzi, Giulia Giannini, Giulia Giannini, Sabina Cevoli, Giulia Pierangeli, Giulia Pierangeli, Pietro Cortelli, Pietro Cortelli, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Chiara Pirazzini
Published 2020-06-01

The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging

by Harry J. Whitwell, Maria Giulia Bacalini, Oleg Blyuss, Oleg Blyuss, Shangbin Chen, Paolo Garagnani, Susan Yu Gordleeva, Sarika Jalan, Sarika Jalan, Mikhail Ivanchenko, Oleg Kanakov, Valentina Kustikova, Ines P. Mariño, Iosif Meyerov, Ekkehard Ullner, Claudio Franceschi, Claudio Franceschi, Alexey Zaikin, Alexey Zaikin, Alexey Zaikin
Published 2020-05-01

A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration

by Camilla Pellegrini, Chiara Pirazzini, Claudia Sala, Luisa Sambati, Luisa Sambati, Igor Yusipov, Alena Kalyakulina, Francesco Ravaioli, Katarzyna M. Kwiatkowska, Danielle F. Durso, Mikhail Ivanchenko, Daniela Monti, Raffaele Lodi, Raffaele Lodi, Claudio Franceschi, Pietro Cortelli, Pietro Cortelli, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Maria Giulia Bacalini
Published 2021-03-01

Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

by Luca Baldelli, Sebastian Schade, Silvia Jesús, Sebastian R. Schreglmann, Luisa Sambati, Pilar Gómez-Garre, Claire Halsband, Giovanna Calandra-Buonaura, Astrid Daniela Adarmes-Gómez, Friederike Sixel-Döring, Corrado Zenesini, Chiara Pirazzini, Paolo Garagnani, Maria Giulia Bacalini, Kailash P. Bhatia, Pietro Cortelli, Brit Mollenhauer, Claudio Franceschi, PROPAG-AGEING consortium, Pablo Mir, Claudia Trenkwalder, Federica Provini
Published 2021-09-01

Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function

by Francesca Ulbar, Tiziana Montemurro, Tatiana Jofra, Miriam Capri, Giorgia Comai, Valentina Bertuzzo, Cristiana Lavazza, Alessandra Mandelli, Mariele Viganò, Silvia Budelli, Maria Giulia Bacalini, Chiara Pirazzini, Paolo Garagnani, Valeria Giudice, Daria Sollazzo, Antonio Curti, Mario Arpinati, Gaetano La Manna, Matteo Cescon, Antonio Daniele Pinna, Claudio Franceschi, Manuela Battaglia, Rosaria Giordano, Lucia Catani, Roberto Massimo Lemoli
Published 2019-08-01

Whole-genome sequencing analysis of semi-supercentenarians

by Paolo Garagnani, Julien Marquis, Massimo Delledonne, Chiara Pirazzini, Elena Marasco, Katarzyna Malgorzata Kwiatkowska, Vincenzo Iannuzzi, Maria Giulia Bacalini, Armand Valsesia, Jerome Carayol, Frederic Raymond, Alberto Ferrarini, Luciano Xumerle, Sebastiano Collino, Daniela Mari, Beatrice Arosio, Martina Casati, Evelyn Ferri, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Donata Luiselli, Davide Pettener, Gastone Castellani, Claudia Sala, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Luca Bertamini, Nicola Martinelli, Domenico Girelli, Oliviero Olivieri, Cristina Giuliani, Patrick Descombes, Claudio Franceschi
Published 2021-05-01

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

by Emanuela Mensà, Michele Guescini, Angelica Giuliani, Maria Giulia Bacalini, Deborah Ramini, Giacomo Corleone, Manuela Ferracin, Gianluca Fulgenzi, Laura Graciotti, Francesco Prattichizzo, Leonardo Sorci, Michela Battistelli, Vladia Monsurrò, Anna Rita Bonfigli, Maurizio Cardelli, Rina Recchioni, Fiorella Marcheselli, Silvia Latini, Serena Maggio, Mirco Fanelli, Stefano Amatori, Gianluca Storci, Antonio Ceriello, Vilberto Stocchi, Maria De Luca, Luca Magnani, Maria Rita Rippo, Antonio Domenico Procopio, Claudia Sala, Iva Budimir, Cristian Bassi, Massimo Negrini, Paolo Garagnani, Claudio Franceschi, Jacopo Sabbatinelli, Massimiliano Bonafè, Fabiola Olivieri
Published 2020-01-01