Implementing sequence-based antigenic distance calculation into immunological shape space model

Implementing sequence-based antigenic distance calculation into immunological shape space model

Abstract Background In 2009, a novel influenza vaccine was distributed worldwide to combat the H1N1 influenza “swine flu” pandemic. However, antibodies induced by the vaccine display differences in their specificity and cross-reactivity dependent on pre-existing immunity. Here, we present a computat...

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Bibliographic Details
Main Authors: Christopher S. Anderson, Mark Y. Sangster, Hongmei Yang, Thomas J. Mariani, Sidhartha Chaudhury, David J. Topham
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Bioinformatics
Subjects:
Gillespie algorithm
Shape space
Antigenic distance
Epitopes
Antigenic sites
Hemagglutinin
Online Access:http://link.springer.com/article/10.1186/s12859-020-03594-3

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http://link.springer.com/article/10.1186/s12859-020-03594-3

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