Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

Generation of autologous human motor neurons holds great promise for cell replacement therapy to treat spinal cord injury (SCI). Direct conversion allows generation of target cells from somatic cells, however, current protocols are not practicable for therapeutic purposes since converted cells are p...

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Bibliographic Details
Main Authors: Hyunah Lee, Hye Yeong Lee, Byeong Eun Lee, Daniela Gerovska, Soo Yong Park, Holm Zaehres, Marcos J Araúzo-Bravo, Jae-Ick Kim, Yoon Ha, Hans R Schöler, Jeong Beom Kim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
direct conversion
induced motor neurons
spinal cord injury
cell replacement therapy
self-renewal
Online Access:https://elifesciences.org/articles/52069

Internet

https://elifesciences.org/articles/52069

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