On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation

On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation

The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract therapy-induced DNA damage. Inhibition of the...

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Bibliographic Details
Main Authors: Nathalie van den Tempel, Alex N. Zelensky, Hanny Odijk, Charlie Laffeber, Christine K. Schmidt, Inger Brandsma, Jeroen Demmers, Przemek M. Krawczyk, Roland Kanaar
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
hyperthermia
homologous recombination
BRCA2
RAD51
ubiquitin
SILAC mass spectrometry
reactive oxygen species
protein degradation
HSP90
Online Access:http://www.mdpi.com/2072-6694/11/1/97

Internet

http://www.mdpi.com/2072-6694/11/1/97

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