Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

Energy-dependent Lon proteases play a key role in cellular regulation by degrading short-lived regulatory proteins and misfolded proteins in the cell. The structure of the catalytically inactive S679A mutant of Escherichia coli LonA protease (EcLon) has been determined by cryo-EM at the resolution o...

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Bibliographic Details
Main Authors: Istvan Botos, George T. Lountos, Weimin Wu, Scott Cherry, Rodolfo Ghirlando, Arsen M. Kudzhaev, Tatyana V. Rotanova, Natalia de Val, Joseph E. Tropea, Alla Gustchina, Alexander Wlodawer
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Current Research in Structural Biology
Subjects:
AAA+ proteins
ATPase module
Lon protease
Cryo-EM
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X19300029

Internet

http://www.sciencedirect.com/science/article/pii/S2665928X19300029

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