Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.

The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade that leads to type I interferon (IFN-α/β) gene transcription. Multiple proteins in this signaling pathway (e.g. RIG-I, MDA5, MAVS, TBK1, IRF3...

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Bibliographic Details
Main Authors: Linda J Visser, Chiara Aloise, Kirby N Swatek, Gisselle N Medina, Karin M Olek, Huib H Rabouw, Raoul J de Groot, Martijn A Langereis, Teresa de Los Santos, David Komander, Tim Skern, Frank J M van Kuppeveld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008702

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https://doi.org/10.1371/journal.ppat.1008702

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