Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer

Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer

Transfer RNA (tRNA) is subject to a multitude of posttranscriptional modifications which can profoundly impact its functionality as the essential adaptor molecule in messenger RNA (mRNA) translation. Therefore, dynamic regulation of tRNA modification in response to environmental changes can tune the...

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Bibliographic Details
Main Authors: Harmen Hawer, Alexander Hammermeister, Keerthiraju Ethiraju Ravichandran, Sebastian Glatt, Raffael Schaffrath, Roland Klassen
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Genes
Subjects:
epitranscriptomics
tRNA
tRNA modification
Elongator
wobble uridine modifications
U34
diphthamide
neurodegeneration
cancer
Online Access:http://www.mdpi.com/2073-4425/10/1/19

Internet

http://www.mdpi.com/2073-4425/10/1/19

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