What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials?
Abstract Background Published in 2019, a new addendum to the ICH E9 guideline presents the estimand framework as a systematic approach to ensure alignment among clinical trial objectives, trial execution/conduct, statistical analyses, and interpretation of results. The use of the estimand framework...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2020-08-01
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Series: | Journal of Patient-Reported Outcomes |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s41687-020-00218-5 |