Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents

Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents

Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4′-chloromethyl-2′-deoxy-2′-fluoro nucleoside ALS-8112, was evaluated in hospitalize...

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Bibliographic Details
Main Authors: Mahesh Kasthuri, Chengwei Li, Kiran Verma, Olivia Ollinger Russell, Lyndsey Dickson, Louise McCormick, Leda Bassit, Franck Amblard, Raymond F. Schinazi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
nucleoside
virus
polymerase inhibitors
respiratory syncytial virus
zika
dengue
west nile
chikungunya
Online Access:https://www.mdpi.com/1420-3049/25/6/1258

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https://www.mdpi.com/1420-3049/25/6/1258

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