A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2

A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2

The nuclear thyroid hormone receptors (THRs) are key mediators of thyroid hormone function on the cellular level <i>via</i> modulation of gene expression. Two different genes encode THRs (<i>THRA</i> and <i>THRB</i>), and are pleiotropically involved in developmen...

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Bibliographic Details
Main Authors: Sarah Paisdzior, Ellen Knierim, Gunnar Kleinau, Heike Biebermann, Heiko Krude, Rachel Straussberg, Markus Schuelke
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
thyroid hormone receptor alpha
resistance to thyroid hormones
gain-of-function
gain-of-antagonistic function
Online Access:https://www.mdpi.com/1422-0067/22/10/5338

Internet

https://www.mdpi.com/1422-0067/22/10/5338

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