Endoplasmic Reticulum–Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival

Endoplasmic Reticulum–Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival

Calcium ions (Ca2+) are crucial, ubiquitous, intracellular second messengers required for functional mitochondrial metabolism during uncontrolled proliferation of cancer cells. The mitochondria and the endoplasmic reticulum (ER) are connected via “mitochondria-associated ER membranes” (MAMs) where E...

Full description

Bibliographic Details
Main Authors: Hristina Ivanova, Martijn Kerkhofs, Rita M. La Rovere, Geert Bultynck
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Oncology
Subjects:
cancer
endoplasmic reticulum–mitochondrial Ca2+ fluxes
Ca2+ signaling
inositol 1,4,5-trisphosphate receptor/Ca2+ channels
cell cycle regulation
mitochondrial metabolism
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00070/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00070/full

Similar Items