A DNA Vaccine Encoding the Gn Ectodomain of Rift Valley Fever Virus Protects Mice via a Humoral Response Decreased by DEC205 Targeting

A DNA Vaccine Encoding the Gn Ectodomain of Rift Valley Fever Virus Protects Mice via a Humoral Response Decreased by DEC205 Targeting

The Rift Valley fever virus (RVFV) is responsible for a serious mosquito-borne viral disease in humans and ruminants. The development of a new and safer vaccine is urgently needed due to the risk of introduction of this arbovirus into RVFV-free continents. We recently showed that a DNA vaccine encod...

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Bibliographic Details
Main Authors: Tiphany Chrun, Sandra Lacôte, Céline Urien, Charles-Adrien Richard, Matthias Tenbusch, Nicolas Aubrey, Coralie Pulido, Latifa Lakhdar, Philippe Marianneau, Isabelle Schwartz-Cornil
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
Rift Valley fever virus
DNA vaccine
dendritic cell
DEC205
Gn glycoprotein
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00860/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00860/full

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