Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide

Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide

Abstract Background Virus-like-particles (VLPs) are attractive nanoparticulate scaffolds for broad applications in material/biological sciences and medicine. Prior their functionalization, specific adaptations have to be carried out. These adjustments frequently lead to disordered particles, but the...

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Bibliographic Details
Main Authors: Jens Schumacher, Tijana Bacic, René Staritzbichler, Matin Daneschdar, Thorsten Klamp, Philipp Arnold, Sabrina Jägle, Özlem Türeci, Jürgen Markl, Ugur Sahin
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Nanobiotechnology
Subjects:
Bionanoparticles
Capsid and particle stability
Chimeric VLP
Computational biology
Molecular mechanism
Structural biology
Online Access:http://link.springer.com/article/10.1186/s12951-018-0363-0

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http://link.springer.com/article/10.1186/s12951-018-0363-0

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