Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation
Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and image the brain accumulation of the PHB.eB capsid b...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15818-4 |