Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.

Hypocatabolism of the amyloid beta-protein (Abeta) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been established whether the proteolytic activity of IDE...

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Bibliographic Details
Main Authors: Christelle Cabrol, Malwina A Huzarska, Christopher Dinolfo, Maria C Rodriguez, Lael Reinstatler, Jake Ni, Li-An Yeh, Gregory D Cuny, Ross L Stein, Dennis J Selkoe, Malcolm A Leissring
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2668070?pdf=render

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http://europepmc.org/articles/PMC2668070?pdf=render

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