Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma

Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma

Medulloblastoma is the most common pediatric malignant brain tumor, arising from aberrant cerebellar precursors' development, a process mainly controlled by Hedgehog (Hh) signaling pathway. Histone deacetylase HDAC1 has been recently shown to modulate Hh signaling, deacetylating its effectors...

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Bibliographic Details
Main Authors: Enrico De Smaele, Lucia Di Marcotullio, Marta Moretti, Marianna Pelloni, Maria Anna Occhione, Paola Infante, Danilo Cucchi, Azzura Greco, Laura Pietrosanti, Jelena Todorovic, Sonia Coni, Gianluca Canettieri, Elisabetta Ferretti, Roberto Bei, Marella Maroder, Isabella Screpanti, Alberto Gulino
Format: Article
Language:English
Published: Elsevier 2011-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800199

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http://www.sciencedirect.com/science/article/pii/S1476558611800199

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