Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways

Hematopoietic stem cells (HSCs) in the fetal liver (FL) unlike adult bone marrow (BM) proliferate extensively, posing different metabolic demands. However, metabolic pathways responsible for the production of energy and cellular building blocks in FL HSCs have not been described. Here, we report tha...

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Bibliographic Details
Main Authors: Javed K. Manesia, Zhuofei Xu, Dorien Broekaert, Ruben Boon, Alex van Vliet, Guy Eelen, Thomas Vanwelden, Steve Stegen, Nick Van Gastel, Alberto Pascual-Montano, Sarah-Maria Fendt, Geert Carmeliet, Peter Carmeliet, Satish Khurana, Catherine M. Verfaillie
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Research
Subjects:
Hematopoietic stem cells
Fetal liver
Bone marrow
Metabolism
Oxidative phosphorylation
Self-renewal
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115001543

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http://www.sciencedirect.com/science/article/pii/S1873506115001543

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