A Phenotarget Approach for Identifying an Alkaloid Interacting with the Tuberculosis Protein Rv1466
In recent years, there has been a revival of interest in phenotypic-based drug discovery (PDD) due to target-based drug discovery (TDD) falling below expectations. Both PDD and TDD have their unique advantages and should be used as complementary methods in drug discovery. The PhenoTarget approach co...
Main Authors: | Yan Xie, Yunjiang Feng, Angela Di Capua, Tin Mak, Garry W. Buchko, Peter J. Myler, Miaomiao Liu, Ronald J. Quinn |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
|
Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/18/3/149 |
Similar Items
-
Discovery of a Natural Product That Binds to the <i>Mycobacterium tuberculosis</i> Protein Rv1466 Using Native Mass Spectrometry
by: Ali R. Elnaas, et al.
Published: (2020-05-01) -
Cross-Examination of Similarity, Difference and Deficiency of Gauge, Radar and Satellite Precipitation Measuring Uncertainties for Extreme Events Using Conventional Metrics and Multiplicative Triple Collocation
by: Zhi Li, et al.
Published: (2020-04-01) -
Can Remote Sensing Technologies Capture the Extreme Precipitation Event and Its Cascading Hydrological Response? A Case Study of Hurricane Harvey Using EF5 Modeling Framework
by: Mengye Chen, et al.
Published: (2020-02-01) -
Validation of Satellite-Based Precipitation Products from TRMM to GPM
by: Jianxin Wang, et al.
Published: (2021-04-01) -
Evaluation of Radar-Rainfall Products over Coastal Louisiana
by: Ridwana Binte Sharif, et al.
Published: (2020-05-01)