MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression

MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression

Paternally-inherited loss-of-function mutations in makorin ring finger protein 3 gene (MKRN3) underlie central precocious puberty. To investigate the puberty-related mechanism(s) of MKRN3 in humans, we generated two distinct bi-allelic MKRN3 knock-out human pluripotent stem cell lines, Del 1 and Del...

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Bibliographic Details
Main Authors: Venkatram Yellapragada, Xiaonan Liu, Carina Lund, Johanna Känsäkoski, Kristiina Pulli, Sanna Vuoristo, Karolina Lundin, Timo Tuuri, Markku Varjosalo, Taneli Raivio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Endocrinology
Subjects:
MKRN3
puberty timing
protein interaction
GNRH1
CRISPR/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00048/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00048/full

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