SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

Summary: One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS-CoV-2 ORF3b is a potent interferon antagonist, suppressing the induction of type I interferon more efficiently than...

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Bibliographic Details
Main Authors: Yoriyuki Konno, Izumi Kimura, Keiya Uriu, Masaya Fukushi, Takashi Irie, Yoshio Koyanagi, Daniel Sauter, Robert J. Gifford, So Nakagawa, Kei Sato
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports
Subjects:
SARS-CoV-2
COVID-19
ORF3b
type I interferon
evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720311748

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720311748

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