Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.

Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of...

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Bibliographic Details
Main Authors: Svetlana Pidasheva, Sara Trifari, Anne Phillips, Jason A Hackney, Yan Ma, Ashley Smith, Sue J Sohn, Hergen Spits, Randall D Little, Timothy W Behrens, Lee Honigberg, Nico Ghilardi, Hilary F Clark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3192060?pdf=render

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http://europepmc.org/articles/PMC3192060?pdf=render

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