Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity

Abstract Background Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied across human tissues and in genetically diverse populations. This has i...

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Bibliographic Details
Main Authors: Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Biology
Subjects:
Single-cell analysis
Alternative splicing
DNA methylation
Splicing prediction
Cell differentiation
Multi-omics
Online Access:http://link.springer.com/article/10.1186/s13059-019-1644-0

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http://link.springer.com/article/10.1186/s13059-019-1644-0

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