Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Effect of Honokiol on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Honokiol is a bioactive component isolated from the medicinal herbs Magnolia officinalis and Magnolia grandiflora that has antioxidative, anti-inflammatory, antithrombotic, and antitumor activities. The inhibitory potentials of honokiol on eight major human cytochrome P450 (CYP) enzymes 1A2, 2A6, 2B...

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Bibliographic Details
Main Authors: Yong Yeon Cho, Jae Young Lee, Jun-Ho Choi, Sung Hum Yeon, Sung-Woon Hong, Soon Sang Kwon, Tae Yeon Kong, Hyeon-Uk Jeong, Hye Suk Lee
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
honokiol
cytochrome P450 inhibition
UDP-glucuronosyltransferase inhibition
human liver microsomes
drug-drug interaction
Online Access:http://www.mdpi.com/1420-3049/18/9/10681

Internet

http://www.mdpi.com/1420-3049/18/9/10681

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