Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation

Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation

In contrast to urodele amphibians and teleost fish, mammals lack the regenerative responses to replace large body parts. Amphibian and fish regeneration uses dedifferentiation, i.e., reversal of differentiated state, as a means to produce progenitor cells to eventually replace damaged tissues. There...

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Bibliographic Details
Main Authors: Atilgan Yilmaz, Rachel Engeler, Simona Constantinescu, Konstantinos D. Kokkaliaris, Christos Dimitrakopoulos, Timm Schroeder, Niko Beerenwinkel, Renato Paro
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Research
Subjects:
Muscle stem cells
Homeobox genes
Tissue regeneration
Reprogramming
Transcription factors
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115001312

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http://www.sciencedirect.com/science/article/pii/S1873506115001312

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