Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Summary: Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is characterized by TDP-43 inclusions and neuroinflammation, but how PGRN loss causes disease remains elusive. We show that Grn...

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Bibliographic Details
Main Authors: Yanwei Wu, Wei Shao, Tiffany W. Todd, Jimei Tong, Mei Yue, Shunsuke Koga, Monica Castanedes-Casey, Ariston L. Librero, Chris W. Lee, Ian R. Mackenzie, Dennis W. Dickson, Yong-Jie Zhang, Leonard Petrucelli, Mercedes Prudencio
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
progranulin
PGRN
granulin
GRN
FTD
lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010159

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http://www.sciencedirect.com/science/article/pii/S2211124721010159

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