Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons

Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons

Abstract The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial (microglial and astrocyte) activation typically occurs early in disease progression and predicts where neuron loss subsequently occ...

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Bibliographic Details
Main Authors: Lotta Parviainen, Sybille Dihanich, Greg W. Anderson, Andrew M. Wong, Helen R. Brooks, Rosella Abeti, Payam Rezaie, Giovanna Lalli, Simon Pope, Simon J. Heales, Hannah M. Mitchison, Brenda P. Williams, Jonathan D. Cooper
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Acta Neuropathologica Communications
Subjects:
Juvenile batten disease
CLN3 disease
Neuronal ceroid lipofuscinosis
Neuron-glial interactions
Astrocyte and microglial dysfunction
Online Access:http://link.springer.com/article/10.1186/s40478-017-0476-y

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http://link.springer.com/article/10.1186/s40478-017-0476-y

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