Inhibiting the Ca2+ Influx Induced by Human CSF

Inhibiting the Ca2+ Influx Induced by Human CSF

One potential therapeutic strategy for Alzheimer’s disease (AD) is to use antibodies that bind to small soluble protein aggregates to reduce their toxic effects. However, these therapies are rarely tested in human CSF before clinical trials because of the lack of sensitive methods that enable the me...

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Bibliographic Details
Main Authors: Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
neurodegenerative conditions
Alzheimer’s disease
cerebrospinal fluid
beta amyloid
oligomers
clusterin
antibodies
single molecule imaging
fluorescence measurements
calcium influx
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317096

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http://www.sciencedirect.com/science/article/pii/S2211124717317096

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