Selective improvement of pulmonary arterial hypertension with a dual ET/ET receptors antagonist in the apolipoprotein E model of PAH and atherosclerosis

Selective improvement of pulmonary arterial hypertension with a dual ET/ET receptors antagonist in the apolipoprotein E model of PAH and atherosclerosis

Idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients who also have an increased risk of co-morbid atherosclerosis. Apolipoprotein E-deficient (ApoE −/− ) mice develop atherosclerosis with severe PAH when fed a high-fat diet (HFD) and have increased levels o...

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Bibliographic Details
Main Authors: Lewis Renshall, Nadine Arnold, Laura West, Adam Braithwaite, Josephine Pickworth, Rachel Walker, Mabruka Alfaidi, Janet Chamberlain, Helen Casbolt, A.A. Roger Thompson, Cathy Holt, Marc Iglarz, Sheila Francis, Allan Lawrie
Format: Article
Language:English
Published: SAGE Publishing 2018-01-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045893217752328

Internet

https://doi.org/10.1177/2045893217752328

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